Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid

作者: Isabelle Valade , David Migneault , Abderrahim Bouzide , Daniel Delorme , Benoit Bachand

DOI:

关键词: In vivoAmino acidOrganic chemistryProdrugMaterials science

摘要: The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1 -propanesulfonic acid (3APS) in a subject, preferably human subject. encompasses compounds that will yield or generate 3APS, either vitro vivo. Preferred include amino prodrugs of 3APS use, including but not limited to, the prevention treatment Alzheimer's disease.

参考文章(344)
Elina Panula-Lehto, Liisa Ahtee, Raimo K. Tuominen, Pekka T. Männistö, Comparison of the effects of intraventricular taurine, GABA and homotaurine on serum prolactin levels in male rats. Pharmacology & Toxicology. ,vol. 65, pp. 152- 156 ,(1989) , 10.1111/J.1600-0773.1989.TB01146.X
Isobel I. J. Sadler, David W. Smith, Mark S. Shearman, C. Ian Ragan, Vipula J. Tailor, Scott J. Pollack, Sulphated compounds attenuate β-amyloid toxicity by inhibiting its association with cells Neuroreport. ,vol. 7, pp. 49- 53 ,(1995) , 10.1097/00001756-199512000-00011
M. Yoshimoto, A. Iwai, D. Kang, D. A. Otero, Y. Xia, T. Saitoh, NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 9141- 9145 ,(1995) , 10.1073/PNAS.92.20.9141
John Littleton, Acamprosate in alcohol dependence: how does it work? Addiction. ,vol. 90, pp. 1179- 1188 ,(1995) , 10.1046/J.1360-0443.1995.90911793.X
A.B Whitworth, H Oberbauer, W.W Fleischhacker, O.M Lesch, H Walter, A Nimmerrichter, T Platz, F Fischer, A Potgieter, Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. The Lancet. ,vol. 347, pp. 1438- 1442 ,(1996) , 10.1016/S0140-6736(96)91682-7
Dana C Hammell, Mohamed Hamad, Haranath K Vaddi, Peter A Crooks, Audra L Stinchcomb, A duplex "Gemini" prodrug of naltrexone for transdermal delivery. Journal of Controlled Release. ,vol. 97, pp. 283- 290 ,(2004) , 10.1016/J.JCONREL.2004.03.020
Henning Sass, Relapse Prevention by Acamprosate Archives of General Psychiatry. ,vol. 53, pp. 673- 680 ,(1996) , 10.1001/ARCHPSYC.1996.01830080023006
Michail E. Kalaitzakis, Manuel B. Graeber, Stephen M. Gentleman, Ronald K. B. Pearce, Striatal β-Amyloid Deposition in Parkinson Disease With Dementia Journal of Neuropathology and Experimental Neurology. ,vol. 67, pp. 155- 161 ,(2008) , 10.1097/NEN.0B013E31816362AA
Jean-Pierre Lhuintre, NicholasD. Moore, Christian Saligaut, Francis Boismare, Martine Daoust, Pierre Chretien, Gilles Tran, Bernard Hillemand, Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics. The Lancet. ,vol. 325, pp. 1014- 1016 ,(1985) , 10.1016/S0140-6736(85)91615-0