Anti-inflammatory effects of Dendrobium nobile derived phenanthrenes in LPS-stimulated murine macrophages
作者： Jeong Hwa Kim , Su-Yeon Oh , Sang-Bae Han , Golam Mezbah Uddin , Chul Young Kim
DOI: 10.1007/S12272-014-0511-5
关键词:
摘要: Dendrobium nobile belongs to the Orchidaceae family and is one of medicinal herbs used in traditional Chinese medicine as a therapeutic agent for gastrointestinal cardiovascular diseases. In this study, we separated three phenanthrenes (ephemeranthol A (EA), 1,5,7-trimethoxyphenanthren-2-ol (TP), dehydroorchinol (DO)) from D. nobile, compared their anti-inflammatory activities. TP new phenanthrene compound its structure was determined 1H, 13C NMR HR-ESI-MS data. To analyze activities phenanthrenes, Raw 264.7 cells were used, since they are immature-macrophages easily matured by LPS stimulation. EA DO showed activated cells. That is, that potent inhibitor production nitric oxide pro-inflammatory cytokines. The inhibitory found be caused blockage NF-κB activation phosphorylation MAP kinases macrophages. These results expected serve guide future studies on ability inhibit acute chronic inflammatory
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