Genome Editing in Mice Using TALE Nucleases.
作者： Benedikt Wefers , Christina Brandl , Oskar Ortiz , Wolfgang Wurst , Ralf Kühn
DOI: 10.1007/978-1-4939-2932-0_17
关键词:
摘要: Gene engineering for generating targeted mouse mutants is a key technology biomedical research. Using TALENs as sequence-specific nucleases to induce double-strand breaks, the genome can be directly modified in zygotes single step without need embryonic stem cells. By embryo microinjection of TALEN mRNAs and targeting vectors, knockout knock-in alleles generated fast efficiently. In this chapter we provide protocols application zygotes.
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