A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein
作者： Neil R. Pumford , Brian M. Martin , Jack A. Hinson
DOI: 10.1016/0006-291X(92)91881-P
关键词:
摘要: Acetaminophen is metabolized by cytochrome P450 to a reactive metabolite that covalently binds proteins and this binding correlates with the hepatotoxicity. The major protein adduct was previously reported be 55 kDa detected on Western blots using antisera specific for 3-(cystein-S-yl)acetaminophen. In study, isolated combination of ion exchange fast flow chromatography, hydroxyapatite HPLC anion HPLC. Amino acid sequences 8 internal peptides from trypsin digestion were found have 97% homology deduced amino sequence cDNA corresponds 56 selenium protein. This first report which acetaminophen binds.
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