Albendazole Treatment of Children with Ascariasis Enhances the Vibriocidal Antibody Response to the Live Attenuated Oral Cholera Vaccine CVD 103-HgR

摘要: Because concurrent infections with geohelminth parasites might impair the immune response to oral vaccines, we studied vibriocidal antibody cholera vaccine CVD 103-HgR in children infected Ascaris lumbricoides and investigated effect of albendazole pretreatment on postvaccination response. Children ascariasis were randomized receive either 2 sequential doses 400 mg or placebo. After second dose, was given, serum levels measured before 10 days after vaccination. Postvaccination rates seroconversion greater treatment group that received ( ). Significantly seroconP p .06 version geometric mean titer observed subjects non-O ABO blood groups. A significant association between group, suggesting A. vaccine, particularly Helminth are estimated infect 3 billion humans worldwide most prevalent poorer regions developing world. Most these due intestinal helminths (or geohelminths), infection which has been associated childhood morbidity, including stunted growth [1], poor cognitive performance [2], malabsorption [1, 3]. Malabsorption resulting macronutrient micronutrient deficiencies is closely those geohelminths inhabit small intestines, namely 4], hookworm [5], Strongyloides stercoralis [6]. We have postulated presence bowel not only affect absorption nutrients but also may interfere attachment vaccines M cells overlie gut-associated lymphoid tissue at mucosal surface.