Chromosomal Aberrations in Squamous Cell Carcinoma and Solar Keratoses Revealed by Comparative Genomic Hybridization
作者： Kevin J. Ashton , Stephen R. Weinstein , David J. Maguire , Lyn R. Griffiths
DOI: 10.1001/ARCHDERM.139.7.876
关键词:
摘要: Objective To identify chromosomal copy numbers of frequent genetic aberrations within squamous cell carcinomas (SCCs) and solar keratoses (SKs), provide further evidence to support or challenge current dogma concerning the relationship between these lesions. Design Retrospective analysis in DNA from SK SCC biopsy specimens by comparative genomic hybridization. Setting University-based research laboratory Queensland, Australia. Patients Twenty-two patients with diagnosed SKs (n = 7), cutaneous SCCs 10), adjoining lesions 5). Main Outcome Measure Identification both specific shared investigate their clonal relationship. Results Shared imbalances were identified SCC. Frequent gains located at chromosome arms 3q, 17q, 4p, 14q, Xq, 5p, 9q, 8q, 17p, 20q, whereas regional losses observed 9p, 3p, 13q, 11p, 18p. Significant loss 18q was only Conclusions Our results demonstrate that numerous are 2 lesions, suggesting a Additionally, may be significant event progression Finally, type frequency suggests common mode tumorigenesis SCC-derived tumors.
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