Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir.
作者： U. Lopatin , H.W. Reesink , A. de Niet , R.B. Takkenberg , R. Benayed
DOI: 10.3109/00365521.2011.648952
关键词:
摘要: In a cohort of 95 chronic hepatitis B patients, who were treated with peg-interferon and adefovir for 1 year, had 15% HBsAg loss (overall), no association was found between IL28B polymorphisms HBeAg seroconversion or clearance. These findings suggest that any outcome, if present, is less than seen in C. Additional studies are needed to enlarge sample size refine our understanding biology the context response immunomodulatory direct antiviral therapy.
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