Downregulation of cytokine-induced neutrophil chemoattractant and prolongation of rat liver allograft survival by interleukin-10.

摘要: We investigated whether the administration of recombinant human interleukin-10 (rhIL-10) regulates production cytokine-induced neutrophil chemoattractant (CINC) and improves graft survival in rat orthotopic liver transplantation (OLTx). Allograft recipients received injections rhIL-10 at doses 2, 10, 20, or 50 micrograms/kg/day. The allograft that 10 20 micrograms/kg/day showed a slight but significant prolongation to 13.0 +/- 0.4 13.8 0.3 days, respectively, compared with 9.6 0.2 days untreated allografts. Conversely, high-dose shortened survival. In treatment groups, mean serum tissue levels CINC every time point after OLTx were reduced significantly those no-treatment group. peak counts peripheral circulation (PC) groups given from samples obtained 12h reperfusion decreased Furthermore, PC between postoperative (PODs) 7 magnitude damage leukocyte infiltration rhIL-10-treated allografts on PODs 1 was Our data indicate downregulates during period injury acute cellular rejection OLTx, prolongs survival, suggesting IL-10 therapy is potentially beneficial OLTx.