Diagnostic Efficacy of PET-FDG Imaging in Solitary Pulmonary Nodules* Potential Role in Evaluation and Management

摘要: Background Positron emission tomography (PET), a new noninvasive imaging modality, utilizing 2-[F-18]-fluoro-2-deoxy-D-glucose (FDC), has demonstrated increased FDC uptake in lung tumors. Objective To determine the diagnostic efficacy of PET-FDG differentiating benign from malignant solitary pulmonary nodules. Patient selection A prospective study 30 patients who presented with indeterminate nodules less than 3 cm size based on chest radiograph and computed tomographic (CT) scan. Setting Two tertiary care medical centers Omaha, Neb: Creighton University Medical Center Omaha Veterans Administration Center. Measurements was performed 1 h after intravenous injection 10 mCi F-18-FDG. Qualitative analysis images independently by two observers visual identification areas Semiquantitative using computation differential ratio (DUR). Histologic specimens were obtained 29 (thoracotomy 20, transthoracic needle aspiration biopsy 8, bronchoscopy1). Results correctly identified 27 Diagnostic accuracy high sensitivity 95 percent specificity 80 percent. The positive negative predictive value PET for 90 89 percent, respectively. DUR values significantly higher (mean± SD, 5.55 ±2.79) (mean±SD, 0.95 ±0.99) (p Conclusion PET-FDC lung, test, degree could complement CT scanning evaluation treatment