Intratracheal administration of third-generation lentivirus vector encoding MPT51 from Mycobacterium tuberculosis induces specific CD8+ T-cell responses in the lung

摘要: The present study evaluates the potential of improved third-generation lentivirus vector with respect to their use as an in vivo-administered T-cell vaccine against tuberculosis. Intratracheal administration encoding MPT51 Mycobacterium tuberculosis could induce MPT51-specific CD8+ T cells mediastinal lymph nodes 2 weeks after administration. vaccination generate memory lung, but not nodes. Further, a single intratracheal immunization lentiviral decreased significantly number virulent M. lung challenge bacillus. These findings suggest that vaccines is promising strategy pulmonary