Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage

摘要: Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid subchondral bone. Thus, nutrient availability limited by matrix permeability according to the size charge of molecules. Matrix composition limits access molecules chondrocytes, determining cell maintenance. Lipids are important nutrients in chondrocyte available for these cells through de novo synthesis but also surrounding tissues. status osteoarthritis development depend lipid availability. This paper reviews transport cartilage. We analyze signalling pathways directly mediated lipids those that involve mTOR pathways, both normal osteoarthritic