TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

摘要: Osteoarthritis (OA), the most common rheumatic disease, is characterized by joint-space narrowing due to progressive cartilage degradation and alterations in subchondral bone synovial membrane. These articular disturbances can have severe consequences, including pain, disability loss of joint architectural integrity. Although aetiology OA not understood, chondrocyte-mediated inflammatory responses triggered activation innate immune receptors damage-associated molecules are thought be involved. In this Review, we examine relationship between Toll-like receptor 4 (TLR4) as well other OA-affected tissues, such synovium. We also discuss different TLR4 agonists associated with their effects tissues. Finally, describe existing novel strategies that might used develop TLR4-specific disease-modifying drugs (DMOADs).