Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man.
作者： J. J. P. Bogaards , M. Bertrand , P. Jackson , M. J. Oudshoorn , R. J. Weaver
DOI: 10.1080/00498250010021684
关键词:
摘要: 1. In the present study, nine cytochrome P450 enzyme activities in seven species were characterized to allow a practical means of comparing this important metabolic step between various test animals and man. 2. Enzyme kinetic parameters first determined towards marker substrates for human enzymes. Inhibition profiles then with both antibodies directed against enzymes chemical inhibitors. 3. Both parameters/enzyme activities, inhibition obtained animal compared those liver microsomes order postulate most similar man regard each individual activity. 4. It was found that, as expected, none tested all measured but that only some could be considered 5. When it is known which are involved metabolism compound, comparative data presented here can used selecting suitable vitro no experiments.
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