Suppression of plasma renin activity by cyclosporine

摘要: Abstract Cyclosporine treatment is associated with hypertension and suppression of plasma renin activity, the causes which are unclear. To determine whether suppressed activity due to extracellular fluid volume expansion, 10 cyclosporine-treated renal transplant recipients were compared azathioprine-treated seven patients insufficiency. Glomerular filtration rate effective flow significantly lower in than patients. Upright was (cyclosporine 2.9 ± 0.9, azathioprine 4.7 insufficiency 5.2 1.9 ng/ml/hour) but could be stimulated by a four-day period dietary sodium restriction diuretic administration (cyclosporine) 15.8 4.4 ng/ml/hour). Extracellular tended higher 30.7 2.3, 26.7 2.5, 25.5 1.4 percent lean body mass), although difference between did not attain statistical significance. There no differences urinary excretion prostaglandin E 2 or 6-keto F 1α two groups recipients. It concluded that cyclosporine physiologic may reflect expansion volume, can reversed depletion.