In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells.

摘要: Neuroregeneration in the CNS has proven to be difficult despite decades of research. The old dogma that CNS neurons cannot regenerated adult mammalian brain been overturned; however, endogenous neurogenesis appears insufficient for repair. Stem cell therapy once held promise generating large quantities CNS, but immunorejection and long-term functional integration remain major hurdles. In this Perspective, we discuss use in vivo reprogramming as an emerging technology regenerate from glial cells inside spinal cord. Besides demonstrated successfully pancreas, heart, liver may adopted other organs. Although challenges translating into clinical therapies, anticipate that revolutionize regenerative medicine by using a patient's own internal tissue