Functional regeneration beyond the glial scar.
作者： Jared M. Cregg , Marc A. DePaul , Angela R. Filous , Bradley T. Lang , Amanda Tran
DOI: 10.1016/J.EXPNEUROL.2013.12.024
关键词:
摘要: Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in lesion core and synthesize connective tissue elements that contribute fibrosis. Oligodendrocyte precursor proliferate within entrap dystrophic axon tips. Here we review evidence this aggregate scar acts as major barrier regeneration axons after injury. We also consider several exciting new interventions allow regenerate beyond glial scar, discuss implications work for future biology.
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