High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma.
作者： Jocelyne Jacquemier , François Bertucci , Pascal Finetti , Benjamin Esterni , Emmanuelle Charafe-Jauffret
DOI: 10.1002/IJC.25979
关键词:
摘要: Medullary breast cancer (MBC) is a basal-like carcinoma (BLBC) with favourable outcome, whereas nonmedullary BLBC has poor prognosis. Tumour infiltrating lymphocytes (TILs) are present in both MBC and BLBC. We hypothesized that the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) could modulate TILs effects among these tumours explain their different outcomes. The amount of IDO expression were analysed using immunohistochemistry (IHC) 155 BC cases including (n = 17), atypical 13) non-MBC 125). Messenger RNA INDO gene, which encodes IDO, was measured 262 from our institution. mRNA histoclinical data 1,487 collected public databases. immunostaining neoplastic stromal cells 100% associated histological medullary features cases. There significant correlation between positivity TIL amounts. In series mostly grade-3 BC, most marker (p 0.02) better survival multivariate analysis. Among cases, showed overexpression as compared to luminal A tumours, non-MBC. pooled 1,749 overexpressed predictor this subtype analysis 0.0024). conclusion, high morphological an independent prognostic value
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