Effect of hypotonic 0.18% sodium hyaluronate eyedrops on inflammation of the ocular surface in experimental dry eye.
作者： Han Jin Oh , Zhengri Li , Soo-Hyun Park , Kyung Chul Yoon
关键词:
摘要: Abstract Purpose: To investigate the efficacy of hypotonic 0.18% sodium hyaluronate (SH) eyedrops in a mouse model experimental dry eye (EDE). Methods: EDE was induced C57BL/6 mice by subcutaneous scopolamine injection and an air draft. The were divided into 4 groups according to topical treatment regimens: control, isotonic 0.5% carboxymethycellulose (CMC), 0.1% SH, SH. Tear volume, corneal smoothness, staining scores measured at 5 10 days EDE. Multiplex immunobead assay, immunohistochemistry, flow cytometry for proinflammatory cytokines, chemokines, inflammatory molecules performed Results: SH group had significantly lower smoothness than CMC (P<0.05). showed low levels tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, monokine interferon-γ, interferon-γ-inducible ...
sci-hub.se 参考文章(46)
Balakrishna L. Lokeshwar, Balakrishna L. Lokeshwar, Min Wang, Michael E. Stern, De Quan Li, Stephen C. Pflugfelder, Dilek Dursun, Dagoberto Monroy, A mouse model of keratoconjunctivitis sicca. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 632- 638 ,(2002)
Linn Jg, Stuart Jc, Dilute sodium hyaluronate (Healon) in the treatment of ocular surface disorders. Annals of Ophthalmology. ,vol. 17, pp. 190- 192 ,(1985)
John M. Tiffany, Viscoelastic Properties of Human Tears and Polymer Solutions Advances in Experimental Medicine and Biology. ,vol. 350, pp. 267- 270 ,(1994) , 10.1007/978-1-4615-2417-5_45
C. Baudouin, F. Brignole, M. De Saint Jean, A. Goguel, M. Goldschild, P.-J. Pisella, Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1356- 1363 ,(2000)
Cees Van Kooten, Jacques Banchereau, CD40-CD40 LIGAND : A MULTIFUNCTIONAL RECEPTOR-LIGAND PAIR Advances in Immunology. ,vol. 61, pp. 1- 77 ,(1996) , 10.1016/S0065-2776(08)60865-2
Jayne Lesley, Robert Hyman, Paul W. Kincade, CD44 and its interaction with extracellular matrix. Advances in Immunology. ,vol. 54, pp. 271- 335 ,(1993) , 10.1016/S0065-2776(08)60537-4
Jerry Y. Niederkorn, Michael E. Stern, Stephen C. Pflugfelder, Cintia S. De Paiva, Rosa M. Corrales, Jianping Gao, Karyn Siemasko, Desiccating Stress Induces T Cell-Mediated Sjögren’s Syndrome-Like Lacrimal Keratoconjunctivitis Journal of Immunology. ,vol. 176, pp. 3950- 3957 ,(2006) , 10.4049/JIMMUNOL.176.7.3950
Yukari Ohmichi, Jotaro Hirakawa, Yasuyuki Imai, Minoru Fukuda, Hiroto Kawashima, Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. Journal of Experimental Medicine. ,vol. 208, pp. 1015- 1025 ,(2011) , 10.1084/JEM.20101786
R Bruce Grene, Penny Lankston, Julie Mordaunt, Marsha Harrold, Arlene Gwon, Robert Jones, Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. Cornea. ,vol. 11, pp. 294- 301 ,(1992) , 10.1097/00003226-199207000-00004
Cintia S. De Paiva, Rosa M. Corrales, Arturo L. Villarreal, William J. Farley, De-Quan Li, Michael E. Stern, Stephen C. Pflugfelder, Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Experimental Eye Research. ,vol. 83, pp. 526- 535 ,(2006) , 10.1016/J.EXER.2006.02.004