Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.

作者: Cintia S. De Paiva , Rosa M. Corrales , Arturo L. Villarreal , William J. Farley , De-Quan Li

DOI: 10.1016/J.EXER.2006.02.004

关键词:

摘要: … MMP-9 expression in the cornea epithelia was evaluated by … in situ zymography and MMP-9 activity in tear washings was … /group/experiment, in three different sets of experiments) were …

参考文章(58)
Balakrishna L. Lokeshwar, Balakrishna L. Lokeshwar, Min Wang, Michael E. Stern, De Quan Li, Stephen C. Pflugfelder, Dilek Dursun, Dagoberto Monroy, A mouse model of keratoconjunctivitis sicca. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 632- 638 ,(2002)
H. W. Hirte, G. Singh, W. C. M. Duivenvoorden, Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Invasion & Metastasis. ,vol. 17, pp. 312- 322 ,(1997)
D J Galarreta, R M Corrales, M Calonge, F J Chaves, J M Herreras, [Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes]. Archivos de la Sociedad Espanola de Oftalmologia. ,vol. 78, pp. 375- 381 ,(2003)
Stephen C. Pflugfelder, Dilek Dursun, Zuguo Liu, Zuguo Liu, Yuhuan Xie, Yuhuan Xie, Abraham Solomon, Angelo Macri, Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 2283- 2292 ,(2001)
S. S. Atherton, Zhonghua Ji, S. C. Pflugfelder, D. Monroy, D. T. Jones, Sjogren's Syndrome: Cytokine and Epstein-Barr Viral Gene Expression Within the Conjunctival Epithelium Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 3493- 3504 ,(1994)
DQ Li, Z Chen, XJ Song, W Farley, SC Pflugfelder, None, Hyperosmolarity Stimulates Production of MMP-9, IL-1ß and TNF- by Human Corneal Epithelial Cells Via a c-Jun NH2-terminal Kinase Pathway Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 1981- 1981 ,(2002)
CS De Paiva, RM Corrales, AL Villarreal, W Farley, D–Q Li, ME Stern, SC Pflugfelder, None, Anti–Inflammatory Therapy Preserves Corneal Barrier Function in Experimental Murine Dry Eye Investigative Ophthalmology & Visual Science. ,vol. 46, pp. 2423- 2423 ,(2005)
Lucia Sobrin, Balakrishna Lokeshwar, Stephen C. Pflugfelder, Marie Selzer, Adolfo A. Afonso, Dagoberto C. Monroy, Tear fluid gelatinase B activity correlates with IL-1α concentration and fluorescein clearance in ocular rosacea Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 2506- 2512 ,(1999)
Lucia Sobrin, Balakrishna L. Lokeshwar, Zuguo Liu, Marie G. Selzer, Stephen C. Pflugfelder, Abraham Solomon, Dagoberto C. Monroy, Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1703- 1709 ,(2000)
Cathy A McCarty, Aashish K Bansal, Patricia M Livingston, Yury L Stanislavsky, Hugh R Taylor, The epidemiology of dry eye in Melbourne, Australia Ophthalmology. ,vol. 105, pp. 1114- 1119 ,(1998) , 10.1016/S0161-6420(98)96016-X