Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity
作者： Olga A. Kraevaya , Alexander S. Peregudov , Ivan A. Godovikov , Elena V. Shchurik , Vyacheslav M. Martynenko
DOI: 10.1039/C9CC08400B
关键词:
摘要: We report unprecedented Friedel–Crafts arylation of chlorofullerenes C60Cl6 and C70Cl8 with unprotected carboxylic acids as an efficient single-step synthesis the inherently stable water-soluble fullerene derivatives. Using this method, a series previously unaccessible compounds was obtained without chromatographic purification in almost quantitative yields. Promising anti-HIV activity comparable to characteristics commercial drugs demonstrated for some these compounds.
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