Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity
作者： Tatiana N. Pashirova , Irina V. Zueva , Konstantin A. Petrov , Vasily M. Babaev , Svetlana S. Lukashenko
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摘要: Solid lipid nanoparticles (SLNs) are among the most promising nanocarriers to target blood–brain barrier (BBB) for drug delivery central nervous system (CNS). Encapsulation of acetylcholinesterase reactivator, pralidoxime chloride (2-PAM), in SLNs appears be a suitable strategy protection against poisoning by organophosphorus agents (OPs) and postexposure treatment. 2-PAM-loaded were developed brain targeting via intravenous (iv) administration. 2-PAM–SLNs displayed high 2-PAM encapsulation efficiency (∼90%) loading capacity (maximum 30.8 ± 1%). Drug-loaded particles had mean hydrodynamic diameter close 100 nm negative zeta potential (−54 −15 mV). These properties contribute improve long-term stability when stored both at room temperature (22 °C) 4 °C, as well longer circulation time bloodstream compared free 2-PAM. Paraoxon-poisoned rats (2 × LD50) treated with dose 2-...
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