Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye.

摘要: While fs-lasers are clinically established for surgery in the anterior eye, their use posterior eye is impeded by aberrations and focus position errors. We implemented a laboratory system to investigate whether fs-laser made more feasible aberration correction tomographic image guidance. Aberration obtained adaptive optics (AO) guidance accomplished optical coherence tomography (OCT). System characteristic measurements cutting experiments were performed inside an model. By correction, wavefront errors reduced from 270 nm root-mean-square (rms) 64 nm rms, ignoring Zernike terms tilts focus. The Strehl ratio of assigned point spread function improved 0.11 0.78. threshold pulse energy laser-induced breakdown water lowered about 3.0 1.3  μJ measured at model entrance. After laser synthetic foil placed 300  μm front porcine retinal tissue with corrected system, postoperative three-dimensional OCT imaging showed no lesions tissue. Our results corroborate that AO will be two essential assistive components possible clinical systems fs-laser–based eye.