Absence of the t(2;5) in Hodgkin's disease.
作者： LM Weiss , JR Lopategui , LH Sun , OW Kamel , CH Koo
DOI: 10.1182/BLOOD.V85.10.2845.BLOODJOURNAL85102845
关键词:
摘要: The cytogenetics of Hodgkin's disease (HD) is poorly understood. However, a t(2;5) common finding in CD30+ anaplastic large cell lymphoma (ALCL), neoplasm thought by some to be closely related HD. Recently, the has been cloned and found represent fusion NPM gene with ALK gene. Using Southern blot hybridization, one group reported rearrangements proportion cases both ALCL In current study, we used highly sensitive reverse transcriptase-polymerase chain reaction methodology analyze 34 HD for t(2;5). We were unable find polymerase evidence any HD, result significantly different from our previous study non-Hodgkin's lymphomas (P < .02) including .04), using identical methods. Our results do not support hypothesis that represents chromosomal abnormality ALCL.
ashpublications.org
sci-hub.se 参考文章(21)
H Tilly, C Bastard, T Delastre, C Duval, M Bizet, B Lenormand, JP Dauce, M Monconduit, H Piguet, Cytogenetic studies in untreated Hodgkin's disease. Blood. ,vol. 77, pp. 1298- 1304 ,(1991) , 10.1182/BLOOD.V77.6.1298.1298
J W Vardiman, M M Le Beau, M A Bitter, R A Larson, C M Rubin, E D Ellis, L A Doane, W A Franklin, M E Kadin, The t(2;5)(p23;q35): a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma. Leukemia. ,vol. 3, pp. 866- 870 ,(1989)
Maya Thangavelu, Michelle M. Le Beau, Chromosomal Abnormalities in Hodgkin’s Disease Hematology/Oncology Clinics of North America. ,vol. 3, pp. 221- 236 ,(1989) , 10.1016/S0889-8588(18)30552-5
H Stein, DY Mason, J Gerdes, N O'Connor, J Wainscoat, G Pallesen, K Gatter, B Falini, G Delsol, H Lemke, R Schwarting, K Lennert, The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. ,vol. 66, pp. 848- 858 ,(1985) , 10.1182/BLOOD.V66.4.848.848
F. Bullrich, M. Hummel, S. Pileri, C. M. Croce, S. W. Morris, H. Stein, Nucleophosmin (NPM) Gene Rearrangements in Ki-1-positive Lymphomas Cancer Research. ,vol. 54, pp. 2873- 2877 ,(1994)
H Merz, FA Houssiau, K Orscheschek, JC Renauld, A Fliedner, M Herin, H Noel, M Kadin, HK Mueller-Hermelink, J Van Snick, Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and large cell anaplastic lymphoma. Blood. ,vol. 78, pp. 1311- 1317 ,(1991) , 10.1182/BLOOD.V78.5.1311.1311
E. S. Jaffe, K. Yang, S. M. Hsu, Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease. American Journal of Pathology. ,vol. 118, pp. 209- 217 ,(1985)
Harald Stein, Johannes Gerdes, Ulrich Schwab, Hilmar Lemke, David Y. Mason, Andreas Ziegler, Wolfgang Schienle, Volker Diehl, Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population International Journal of Cancer. ,vol. 30, pp. 445- 459 ,(1982) , 10.1002/IJC.2910300411
K. Orscheschek, H. Merz, J. Hell, A.C. Feller, H. Bartels, T. Binder, Large-cell anaplastic lymphoma-specific translocation (t[2;5] [p23;q35]) in Hodgkin's disease: indication of a common pathogenesis? The Lancet. ,vol. 345, pp. 87- 90 ,(1995) , 10.1016/S0140-6736(95)90061-6
C. Bastard, Ruth Rimokh, Nicole Dastugue, J-L. Huret, U. Kristoffersson, J-P. Magaud, C. Nezelof, H. Tilly, J-P. Vannier, J. Hemet, R. Warnke, CD30-positive large cell lymphomas ('Ki-1 lymphoma') are associated with a chromosomal translocation involving 5q35 British Journal of Haematology. ,vol. 74, pp. 161- 168 ,(1990) , 10.1111/J.1365-2141.1990.TB02560.X