Variability of trabecular microstructure is age-, gender-, race- and anatomic site-dependent and affects stiffness and stress distribution properties of human vertebral cancellous bone

摘要: Abstract Cancellous bone microstructure is an important determinant of the mechanical integrity vertebrae. The numerous microstructural parameters that have been studied extensively are generally represented as a single value obtained average over sample. range intra-sample variability cancellous and its effect on properties less well-understood. objectives this study were to investigate extent which human within vertebra i) related modulus stress distribution ii) changes along with age, gender locations thoracic 12 (T12) vs lumbar 1 (L1). Vertebrae collected from 15 male (66 ± 15 years) 25 female (54 ± 16 years) cadavers. Three dimensional finite element models constructed using microcomputed tomography images cylindrical specimens. Linear used estimate apparent in cylinders during uniaxial compression. intra-specimen mean, standard deviation (SD) coefficient variation (CV) variables calculated. Mixed model statistical analysis results demonstrated increases contribute trabecular stresses decreases stiffness. These effects independent contribution microstructure. Further, stiffness not accounted for by connectivity anisotropy. Microstructural (SD, CV) increased greater females than males T12 L1. Significant interactions found between gender, race. suggest varied age differently genders, races vertebral levels. current collectively demonstrate has significant tissue bone. Considering could improve understanding fragility assessment fracture risk.