Digital tomosynthesis (DTS) for quantitative assessment of trabecular microstructure in human vertebral bone
作者： Woong Kim , Daniel Oravec , Srikant Nekkanty , Janardhan Yerramshetty , Edward A. Sander
DOI: 10.1016/J.MEDENGPHY.2014.11.005
关键词: Coronal plane 、 Materials science 、 Biomedical engineering 、 Tomography 、 Cancellous bone 、 Stereology 、 Radiography 、 Standard deviation 、 Tomosynthesis 、 Nuclear medicine 、 Spinal fracture
摘要: Abstract Digital tomosynthesis (DTS) provides slice images of an object using conventional radiographic methods with high in-plane resolution. The objective this study was to explore the potential DTS for describing microstructural, stiffness and stress distribution properties vertebral cancellous bone. Forty vertebrae (T6, T8, T11, L3) from 10 cadavers (63–90 years) were scanned microCT DTS. Anisotropy (μCT.DA), specimen-average standard deviation trabecular bone volume fraction (BV/TV), thickness (Tb.Th), number (Tb.N) separation (Tb.Sp) obtained stereology. Apparent modulus ( E FEM ), magnitude (VMExp/ σ app ) variability (VMCV) stresses calculated microCT-based finite element modeling. Mean intercept length, line fractal parameters coronal slices, then correlated stereological linear regression models. Twenty-one (out 27) BV/TV, Tb.Th, Tb.N, Tb.Sp and/or μCT.DA p VMCV (by 9–11% 13–19%, respectively; In conclusion, has quantitative assessment may be used as a modality complementary those measuring mass assessing spinal fracture risk.
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