Polyphenol-rich seaweed (Eucheuma cottonii) extract suppresses breast tumour via hormone modulation and apoptosis induction
作者： Farideh Namvar , Suhaila Mohamed , Samaneh Ghasemi Fard , Javad Behravan , Noordin M Mustapha
DOI: 10.1016/J.FOODCHEM.2011.07.054
关键词:
摘要: Abstract The edible red seaweed Eucheuma cottonii is abundantly cultivated for carrageenan production. This study investigated the effects of dietary E. polyphenol-rich extract (ECME) on breast cancer. In vitro assays showed that ECME was antiproliferative against oestrogen-dependent MCF-7 and oestrogen-independent MB-MDA-231 human breast-cancer cells (IC 50 values 20 42 μg/ml, respectively) but non-toxic to normal cell lines. (150 300 mg/kg BW) fed female rats and, after 4 weeks, rat mammary tumour induced using LA7 (inoculated subcutaneously). inhibited development erythrocyte lipid peroxidation in cancer-induced rats, dose-dependently. It anti-oestrogenic estrous cycle serum hormone levels. Electron microscopy histopathology observations confirmed apoptosis tumours. tumour-suppressive via induction, downregulating endogenous oestrogen biosynthesis, improving antioxidative status rats.
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