Brown Kelp Modulates Endocrine Hormones in Female Sprague-Dawley Rats and in Human Luteinized Granulosa Cells

摘要: Epidemiological studies suggest that populations consuming typical Asian diets have a lower incidence of hormone-dependent cancers than Western diets. These dietary differences been mainly attributed to higher soy intakes among Asians. However, from our laboratory the anti-estrogenic effects kelp also may contribute these reduced cancer rates. As follow-up previous findings endocrine modulation related ingestion in pilot study premenopausal women, we investigated modulating (Fucus vesiculosus) female rats and human luteinized granulosa cells (hLGC). Kelp administration lengthened rat estrous cycle 4.3 +/- 0.96 5.4 1.7 d at 175 mg . kg(-1) body wt d(-1) (P = 0.05) 5.9 1.9 350 0.002) led 100% increase length diestrus 0.02). Following treatment for 2 wk, serum 17beta-estradiol levels were 48.9 4.5 40.2 3.2 ng/L 0.13). After 4 36.7 2.2 In hLGC, 25, 50, 75 micromol/L 4732 591 3632 758, 3313 373, 3060 538 ng/L, respectively. modest elevations hLGC culture progesterone levels. extract inhibited binding estradiol estrogen receptor alpha beta receptor, with IC(50) values 42.4, 31.8, 40.7 micromol/L, data show relevant doses Japanese.