Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury.

摘要: Objectives. Body weight–supported treadmill training (BWSTT) is a task-specific rehabilitation strategy that enhances functional locomotion in patients following spinal cord injury (SCI). Supraspinal centers may play animportantroleintherecoveryofover-groundlocomotor function with motor-incomplete SCI. The purpose of this study was to evaluate the potential for supraspinal reorganization associated 12 weeks robotic BWSTT using magnetic resonance imaging (fMRI). Methods. Four men SCI participated study. Time since onset ranged from 14 48 months post-SCI injury. All subjects were trained 3 times weekly weeks. This preceded and followed by fMRI activity during movement task. Testing locomotor disability included Walking Index Spinal Cord Injury (WISCI II) over-ground gait speed. Results. demonstrated some degree change blood-oxygen-level-dependent (BOLD) signal BWSTT. results greater activation sensorimotor cortical regions(S1,S2)andcerebellarregionsfollowingBWSTT. Conclusions. Intensive rehabilitative training, such as BWSTT, can promote plasticity motor known be involved locomotion. Furthermore, improvement accompanied an increased cerebellum.