Mediation of responses to calcium in taste cells by modulation of a potassium conductance.
作者： A. Bigiani , S. Roper
关键词:
摘要: Calcium salts are strong taste stimuli in vertebrate animals. However, the chemosensory transduction mechanisms for calcium not known. In buds of Necturus maculosus (mud puppy), evokes depolarizing receptor potentials by acting extracellularly on apical ends cells to block a resting potassium conductance. Therefore, divalent cations elicit modulating conductance rather than permeating cell membrane, mechanism utilized monovalent such as sodium and ions.
core.ac.uk
harvard.edu
sciencemag.org
elsevier.com参考文章(21)
B. Rudy, Diversity and ubiquity of K channels. Neuroscience. ,vol. 25, pp. 729- 749 ,(1988) , 10.1016/0306-4522(88)90033-4
Keiichi Tonosaki, Masaya Funakoshi, Cyclic nucleotides may mediate taste transduction. Nature. ,vol. 331, pp. 354- 356 ,(1988) , 10.1038/331354A0
Andrew I. Spielman, Istvan Mody, Joseph G. Brand, Glayde Whitney, John F. MacDonald, Michael W. Salter, A method for isolating and patch-clamping single mammalian taste receptor cells. Brain Research. ,vol. 503, pp. 326- 329 ,(1989) , 10.1016/0006-8993(89)91684-3
S C Kinnamon, S D Roper, Membrane properties of isolated mudpuppy taste cells. The Journal of General Physiology. ,vol. 91, pp. 351- 371 ,(1988) , 10.1085/JGP.91.3.351
S D Roper, The Cell Biology of Vertebrate Taste Receptors Annual Review of Neuroscience. ,vol. 12, pp. 329- 353 ,(1989) , 10.1146/ANNUREV.NE.12.030189.001553
C M Armstrong, D R Matteson, The role of calcium ions in the closing of K channels. The Journal of General Physiology. ,vol. 87, pp. 817- 832 ,(1986) , 10.1085/JGP.87.5.817
Susan S. Schiffman, The role of sodium and potassium transport pathways in taste transduction: an overview Chemical Senses. ,vol. 15, pp. 129- 135 ,(1990) , 10.1093/CHEMSE/15.1.129
Yasuyuki KITADA, Inhibitory effects of cations on the Ca2+ response of water fibers in the frog tongue. Japanese Journal of Physiology. ,vol. 28, pp. 413- 422 ,(1978) , 10.2170/JJPHYSIOL.28.413
S. D. Roper, D. W. McBride, Distribution of ion channels on taste cells and its relationship to chemosensory transduction. The Journal of Membrane Biology. ,vol. 109, pp. 29- 39 ,(1989) , 10.1007/BF01870788
S. C. Kinnamon, V. E. Dionne, K. G. Beam, Apical localization of K+ channels in taste cells provides the basis for sour taste transduction. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 7023- 7027 ,(1988) , 10.1073/PNAS.85.18.7023