Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane

摘要: The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality is released at dissolution rate of more than about 80% within first 60 minutes following entry said into use environment. direct compressed has hardness range between 3 40 Kp, average Tmax 2 8 hours with load 2.5 150 mg. formulation allows for dose-proportional compositions once daily b.i.d. dosing, while maintaining steady Tmax.