Microinfusion of the metabotropic glutamate receptor agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid into the nucleus accumbens induces dopamine-dependent locomotor activation in the rat.

摘要: Although the striatum has one of highest densities metabotropic glutamate receptor (mGluR) binding sites in brain, little is known about their physiological role. In this study we characterized contribution mGluRs located ventral part (the nucleus accumbens) to control extrapyramidal motor function. Activation by local infusion selective agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD; 25, 50 and 100 nmol/0.5 microl) into accumbens induced a dose-dependent increase locomotor activity rats. Intra-accumbens antagonist mGluRs, alpha-methyl-4-carboxyphenylglycine (MCPG) did not modify spontaneous locomotion but decreased response 1S,3R-ACPD. This effect appeared be mediated dopamine, since blockade dopamine receptors with haloperidol (0.05 0.1 mg/kg i.p.) dose-dependently reduced 1S,3R-ACPD-induced activation. Furthermore, D-amphetamine (0.5 mg/kg, combined intra-accumbens 1S,3R-ACPD (100 nmol) potentiated hyperactivity higher level than that seen single treatment either drug. contrast, D-amphetamine-induced hypermotility was abolished MCPG accumbens. These results demonstrate may function through receptors. activation appears act synergy system at produce stimulant response.