Decreased glutamate uptake in subcortical areas deafferented by sensorimotor cortical ablation in the cat

作者: AB Young , MB Bromberg , JB Penney

DOI: 10.1523/JNEUROSCI.01-03-00241.1981

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摘要: Evidence that L-glutamate is a neurotransmitter of corticofugal fibers was sought by measuring changes in several biochemical markers function after pericruciate (sensorimotor) ablations cats. Two weeks cortical ablation, samples from various brain regions were analyzed for high affinity uptake glutamate, gama- aminobutyric acid (GABA), glycine, alanine, and tyrosine. Amino levels the activity choline acetyltransferase (CAT) also determined. High glutamate decreased relative to opposite side areas nervous system which lost predominantly unilateral projection. These include caudate nucleus, ventrolateral thalamic red basis pontis, cervical lumbar spinal cord. No significant found other amino acids or CAT these regions. Changes only thalamus where there 33% decrease on deafferented side. The data suggest many subcortical related motor control.

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