作者: AB Young , MB Bromberg , JB Penney
DOI: 10.1523/JNEUROSCI.01-03-00241.1981
关键词:
摘要: Evidence that L-glutamate is a neurotransmitter of corticofugal fibers was sought by measuring changes in several biochemical markers function after pericruciate (sensorimotor) ablations cats. Two weeks cortical ablation, samples from various brain regions were analyzed for high affinity uptake glutamate, gama- aminobutyric acid (GABA), glycine, alanine, and tyrosine. Amino levels the activity choline acetyltransferase (CAT) also determined. High glutamate decreased relative to opposite side areas nervous system which lost predominantly unilateral projection. These include caudate nucleus, ventrolateral thalamic red basis pontis, cervical lumbar spinal cord. No significant found other amino acids or CAT these regions. Changes only thalamus where there 33% decrease on deafferented side. The data suggest many subcortical related motor control.