Neurotransmitters in subcortical somatosensory pathways

摘要: Investigations during recent years indicate that many different neuroactive substances are involved in the transmission and modulation of somesthetic information central nervous system. This review surveys developments within field somatosensory neurotransmission, emphasizing immunocytochemical findings. Increasing evidence indicates a widespread role for glutamate as fast-acting excitatory neurotransmitter at levels pathways. Several studies have substantiated primary afferent neurons corticofugal projections, also ascending Other likely to be neurotransmission include neuropeptides. Many peptides been detected with unmyelinated or thinly myelinated axons, thus directly neurotransmission. Some giving rise pathways, primarily those cell bodies dorsal horn, immunoreactive peptides. Recent investigations shown expression neuropeptides, both tract neurons, may change result various kinds peripheral manipulation. The occurence neurotransmitters intrinsic providing modulating inputs relay nuclei (the lateral cervical nucleus, column ventrobasal thalamus) is reviewed. Neurotransmitters modulators such acetylcholine, monoamines, GABA, glycine, glutamate,