BRAF-mutated colorectal cancer: clinical implications for a distinct subset of the disease

摘要: SUMMARY  Colorectal cancer (CRC) is many diseases, with each case defined by the underlying genetic and molecular changes of that particular tumor. The heterogeneity CRC emphasizes need to understand this disease within context subsets. BRAF mutations mark a subpopulation arises through serrated pathway carcinogenesis. This subset cancers associated unique clinical histopathologic characteristics. BRAF-mutated CRCs have worse prognosis compared their wild-type counterparts, may not be as responsive chemotherapy. Target therapies specifically against its related signaling pathways are under both scientific investigation. article highlights relevance CRCs.