Shining light on nuclear-targeted therapy using gold nanostar constructs.

摘要: Nuclear-targeted therapy has received increasing attention as a potential strategy to improve the therapeutic efficacy of treating cancer. The main challenges include targeting, drug-delivery efficiency and release anticancer agents cancer cell nucleus. Nanoparticles nanocarriers have started address some these issues. However, lack understanding in how nanoconstructs interact with nucleus precluded detailed studies. In this article, we highlight nanoconstruct composed gold (Au) nanostars loaded nucleolin-specific aptamers. This induced major changes nuclear phenotype through envelope (NE) invaginations. Femtosecond, light-triggered aptamers from surface Au further increased number NE deformations. Cancer cells more folding showed apoptosis well decreased viability. author’s article revealed that correlation between drug-induced phenotypes can provide new insight into nuclear-targeted therapy.