Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons.

摘要: Inhibitory interneurons interconnected via electrical and chemical (GABAA receptor) synapses form extensive circuits in several brain regions. They are thought to be involved timing synchronization through fast feedforward control of principal neurons. Theoretical studies have shown, however, that whereas self-inhibition does indeed reduce response duration, lateral inhibition, contrast, may generate slow components a process gradual disinhibition. Here we simulated circuit (stellate basket cells) the molecular layer cerebellar cortex observed time constants could rise, depending on parameter values, >1 s. The integration scaled both with strength vanishing completely when inhibition was blocked, average connection distance, which determined balance between self-inhibition. Electrical further enhance by limiting heterogeneity among introducing capacitive current. model can explain observations, such as course OFF-beam phase lag during vestibular rotation, or lead Purkinje cells. Interestingly, interneuron spike trains displayed power approximately 1/f at low frequencies. In conclusion, stellate cells cortex, general, not only provide but also act temporal integrators build very short-term memory.NEW & NOTEWORTHY most common function attributed inhibitory is many regions, densely this coupling largely unknown. Based large-scale simulations an propose enhances constant, hence memory trace, circuit.