Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies

摘要: Background Vitamin D deficiency, assessed as low 25-hydroxyvitamin (25[OH]D) level, is highly prevalent in patients with chronic kidney disease (CKD) and associated various adverse health outcomes. Whether 25(OH)D levels CKD are an independent risk factor for mortality remains to be studied detail, this was the objective of our work. Study Design A systematic review meta-analysis prospective observational studies. Setting & Population Patients CKD. diagnosed mainly decreased estimated glomerular filtration rate. Selection Criteria Studies We performed a literature search MEDLINE, ISI, EMBASE identify studies reporting on mortality. Predictor serum concentrations. Outcome All-cause Results 10 overall sample 6,853 were included. Relative per 10-ng/mL (25-nmol/L) increase level 0.86 (95% CI, 0.82-0.91), no indication publication bias or significant heterogeneity ( I 2 =15%; P = 0.3). Summary estimates cohorts without dialysis treatment showed homogeneous results 0.9). Limitations may limited by heterogeneity, unconsidered confounders, design Furthermore, unpublished null findings association cannot ruled out ascertainment based largely Conclusions Higher significantly improved survival using natural vitamin supplementation improves elucidated randomized controlled trials.