Inhibitory rnas to rna binding proteins hnrnpa1, hnrnpa2 and ptb and uses thereof

作者: James L. Manley , Charles David , Jian Zhang , Mo Chen

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摘要: Provided herein are methods to reduce or slow down cell growth, for example in a cancer comprising contacting with an effective amount of combination inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. identify agents which the levels increase ratio PKM1/PKM2 proteins, PKM2 levels, PKM1 levels.

参考文章(92)
F. Wong-Staal, G. Liu, Q. X. Li, Development of new RNAi therapeutics Histology and Histopathology. ,vol. 22, pp. 211- 217 ,(2007) , 10.14670/HH-22.211
John C Castle, Chaolin Zhang, Jyoti K Shah, Amit V Kulkarni, Auinash Kalsotra, Thomas A Cooper, Jason M Johnson, Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nature Genetics. ,vol. 40, pp. 1416- 1425 ,(2008) , 10.1038/NG.264
Patrick Y. Lu, Frank Xie, Martin C. Woodle, In vivo application of RNA interference: from functional genomics to therapeutics. Advances in Genetics. ,vol. 54, pp. 115- 142 ,(2005) , 10.1016/S0065-2660(05)54006-9
Gregory N. Fuller, Ian E. McCutcheon, Gilbert J. Cote, Eileen S.C. Huang, Wei Jin, Fibroblast Growth Factor Receptor-1 α-Exon Exclusion and Polypyrimidine Tract-binding Protein in Glioblastoma Multiforme Tumors Cancer Research. ,vol. 60, pp. 1221- 1224 ,(2000)
Giuseppe Biamonti, Maria Teresa Bassi, Luca Cartegni, Fatima Mechta, Massimo Buvoli, Fabio Cobianchi, Silvano Riva, Human hnRNP protein A1 gene expression. Structural and functional characterization of the promoter. Journal of Molecular Biology. ,vol. 230, pp. 77- 89 ,(1993) , 10.1006/JMBI.1993.1127
David M. Shanahan, Donald Rao, Phillip B. Maples, Neil Senzer, I John J. Nemunaitis, Individualized cancer therapy ,(2013)
Brett P. Monia, Lex M. Cowsert, Antisense modulation of hnRNP A1 expression ,(1999)
Michael Ray Gribskov, John Devereux, Sequence Analysis Primer ,(1991)