Safe chemical uncouplers for the treatment of obesity
作者： Birgit Sehested Hansen , Thomas Kruse Hansen , Morten Colding-Joergensen , Soeren Tullin
DOI:
关键词:
摘要: This invention relates to chemical uncouplers with a broader safety window making the use of them in treating obesity and, consequently, treatment related dis-eases and conditions such as atherosclerosis, hypertension, diabetes, especially type 2 dia-betes (NIDDM (non-insulin dependent diabetes mellitus)), impaired glucose tolerance, dyslip-idemia, coronary heart disease, gallbladder osteoarthritis various types can-cer endometrial, breast, prostate colon cancers risk for premature death well other conditions, diseases disorders, which are improved by an increase mitochondrial respiration, more attractive.
lens.org 参考文章(30)
Nicholas Bachynsky, Human weight loss inducing method ,(1984)
Chung Chen Wei, Todd A. Miller, Ruofei Zhang, Ping Huang, Jingrong Cui, Peng Cho Tang, Xiaoyuan Li, 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors ,(2001)
Anne N. Murphy, Amy K. Stout, Screening assays using intramitochondrial calcium ,(2001)
William John Pitts, Donald Joseph Phillip Pinto, Douglas Guy Batt, Michael James Orwat, Joseph James Petraitis, Prostaglandin synthase-2 inhibitors ,(1996)
William P. Dankulich, Terence J. Kiesow, Keith S. Learn, John W. Ullrich, Anthony C. Scotese, Kent W. Neuenschwander, Cycloalkyl amine bis-aryl squalene synthase inhibitors ,(1993)
Didier Mesangeau, Micheline Kergoat, Philippe Maizeray, Lilianne Doare, Gerard Moinet, Pharmaceutical composition containing 4-oxo-butynic acids ,(1997)
Eduardo Marban, Brian O'Rourke, Methods to identify compounds affecting mitochondria ,(1998)
Florencio Zaragoza Dorwald, Knud Erik Andersen, Jan Lindy Sorensen, Substituted piperazines and diazepanes ,(2002)
Peng Cho Tang, Methods of modulating protein tyrosine kinase function with substituted indolinone compounds ,(2001)
Alexander Levitzki, Klaus Peter Hirth, Jianming Tsai, Aviv Gazit, Hui Chen, Elaina Mann, Peng Cho Tang, Laura K. Shawver, Methods and compositions for inhibiting cell proliferative disorders ,(1995)