Isolation, structure elucidation, and synthesis of novel penicillin degradation products: thietan-2-ones
作者： Kirk A. Ashline , Robin P. Attrill , Edward K. Chess , J. Peter Clayton , Ernest A. Cutmore
DOI: 10.1039/P29900001559
关键词:
摘要: High-field nuclear magnetic resonance spectroscopy, mass spectrometry, infrared and ultraviolet spectroscopy were used to determine the structures of two novel degradation productions penicillins sodium nafcillin (1) oxacillin (2). The products compounds (2) found possess thietan-2-one (3)and (4), respectively. structure compound (4) was confirmed by chemical synthesis via independent routes. (3) single-crystal X-ray crystallography.
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