Naloxone effects on sucrose-motivated behavior

摘要: The opioid system plays an important role in feeding. In general, agonists typically increase feeding and antagonists decrease nonfood restricted animals. food animals the effects of these drugs are substantially reduced. Opioid have shown a marked effectiveness at reducing consumption sweet foods. Explanations for this robust effect focused on drug induced changes taste, taste perception, or palatability. current study relates antagonist naloxone motivation to obtain different sucrose concentrations drug's unrestricted solution consumption. Changes respond were assessed under progressive ratio reinforcement schedule (PR) which required increased response cost each successive unit solution. Motivation, as measured by PR, concentration produced dose-dependent given concentration. Thus, was indirectly related strength Under access solutions, reduced greatest higher concentrations. data suggest least part naloxone's tasting may be mediated through endogenous reward systems that reflected measures motivation.