Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort.

摘要: This study assessed the incidence and risk factors for dengue virus (DENV) infection among children in a prospective birth cohort conducted city of Recife, hyperendemic area Northeast Brazil. Healthy pregnant women (n = 415) residing Recife who agreed to have their followed were enrolled. Children during first 24 months age (May/2011-June/2014), before 2015 Zika outbreak. DENV was detected by reverse-transcriptase polymerase chain reaction and/or serology (anti-DENV IgM/IgG). The rates per 1000 person-years (py) its association with bands (0-12, >12-30 months) estimated through Poisson regression models. Forty-nine infections detected; none progressed severe forms. 107·6/1000py (95% CI 76·8-150·6) 93·3/1000py 56·1-154·4) second years age, respectively. Male (risk ratios (RR) 2·33; 95% 1·09-4·98) those born DENV-naive mothers (RR 2·42; 1·01-5·80) at greater year age. In year, Caucasian/Asian descent skin colour had threefold higher 3·34; CI: 1·08-10·33). These data show high exposure our setting highlight role biological this population's susceptibility infection.