The Effect of Antacids on the Absorption of Simultaneously Ingested Iron

摘要: Most discussions of iron therapy include a statement about the ineffectiveness ingested simultaneously with antacids. This study was designed to determine whether or not antacids inhibit absorption. A small-dose tolerance test used compare absorption and without various Liquid antacid containing aluminum hydroxide magnesium did significantly decrease Sodium bicarbonate calcium carbonate caused plasma increase be 50% 67% less than control values, respectively. However, when present in multivitamin-plus-minerals tablet, change different from trials. Presumably competitive binding by ascorbic acid vitamin pill allowed uninhibited iron. Our results suggest that certain may combined reducing efficacy ( JAMA 1986;255:1468-1470)