Tumor Spectrum in ARF-deficient Mice
作者： Charles J. Sherr , Takehiko Kamijo , David H. Randle , Esther van de Kamp , Sara Bodner
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摘要: … of the residual ARF allele and/or lack of ARF mRNA expression, implying that ARF can act as a canonical “two-hit” tumor suppressor gene. Tumors occurred earlier in life in ARF-null …
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