Human periodontal ligament stem cells repair mental nerve injury
作者： Jeong Won Jahng , Hun-Jong Jung , Soung-Min Kim , Myung-Jin Kim , Jong-Ho Lee
DOI: 10.3969/J.ISSN.1673-5374.2013.30.005
关键词:
摘要: Keywords: neural regeneration, peripheral nerve injury, stem cells, periodontal ligament mental nerve, Schwann cell transplantation, sensory neurotrophic factor, neuroregeneration Abstract Human cells are easily accessible and can differentiate into cells. We hypothesized that human be used as an alternative source for the autologous in promoting regeneration of injured nerve. To validate this hypothesis, (1 × 106) were injected crush-injured left rats. Simultaneously, PBS also controls. Real-time reverse transcriptase polymerase chain reaction showed at 5 days after injection, mRNA expression low affinity growth factor receptor was significantaly increased trigeminal ganglion rats with injury. Sensory tests, histomorphometric evaluation retrograde labeling demonstrated 2 4 weeks function significantly improved, numbers labeled neurons myelinated axons increased, exhibited similar therapeutic effects. These findings suggest transplantation show a potential value repair
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