Characteristics and prognosis of patients with colorectal cancer-associated brain metastases in the era of modern systemic chemotherapy

摘要: Brain metastases (BM) occur in approximately 20–40% of cancer patients. The present study investigated the clinical outcomes patients with BM from colorectal (CRC) to assess benefit systemic chemotherapy (CT) administered after surgical or radiotherapeutic control and identify independent prognostic factors associated survival BM. Between August 2001 July 2009, 118 symptomatic CRC received either cranial irradiation craniotomy at two large centers South Korea. Retrospective review statistical analysis characteristics were performed for all Median time diagnosis metastatic detection was 12.2 months (range 0–76.2 months). Thirteen (11%) exhibited brain involvement initial presentation. development 4.1 [95% confidence interval (CI) 3.3–4.9 months]. Forty-six (40%) had been treated previously chemotherapeutic agents fluoropyrimidine, oxaliplatin, irinotecan. Patients who CT significantly improved compared those did not (12.4 versus 3.1 months, respectively; P < 0.001). Multivariate revealed that intervention presentation BM, adjusted hazard ratio 0.30 (95% CI 0.17–0.51, Although is a late-stage phenomenon CRC, two-thirds still unexposed irinotecan oxaliplatin our study. Thus, additional may be beneficial selected