Striatal parvalbuminergic neurons are lost in Huntington's disease: Implications for dystonia

作者: Anton Reiner , Evan Shelby , Hongbing Wang , Zena DeMarch , Yunping Deng

DOI: 10.1002/MDS.25624

关键词:

摘要: Although dystonia represents a major source of motor disability in Huntington's disease (HD), its pathophysiology remains unknown. Because recent animal studies indicate that loss of …

参考文章(72)
Hitoshi Kita, Chapter 4 GABAergic circuits of the striatum Progress in Brain Research. ,vol. 99, pp. 51- 72 ,(1993) , 10.1016/S0079-6123(08)61338-2
Tibor Koós, James M. Tepper, Inhibitory control of neostriatal projection neurons by GABAergic interneurons. Nature Neuroscience. ,vol. 2, pp. 467- 472 ,(1999) , 10.1038/8138
Joseph Jankovic, Christopher A Beck, Ainhi Duy Ha, Intermediate CAG Repeats in Huntington's Disease: Analysis of COHORT Tremor and other hyperkinetic movements (New York, N.Y.). ,vol. 2, pp. 02- ,(2012) , 10.7916/D8FF3R2P
Joel L. Davis, James C. Houk, David G. Beiser, Models of Information Processing in the Basal Ganglia. MIT Press. ,(1995)
Sankari Ramanathan, Jason J. Hanley, Jean-Michel Deniau, J. Paul Bolam, Synaptic Convergence of Motor and Somatosensory Cortical Afferents onto GABAergic Interneurons in the Rat Striatum The Journal of Neuroscience. ,vol. 22, pp. 8158- 8169 ,(2002) , 10.1523/JNEUROSCI.22-18-08158.2002
Manuela Gernert, Mustapha Bennay, Maren Fedrowitz, Jan H. Rehders, Angelika Richter, Altered Discharge Pattern of Basal Ganglia Output Neurons in an Animal Model of Idiopathic Dystonia The Journal of Neuroscience. ,vol. 22, pp. 7244- 7253 ,(2002) , 10.1523/JNEUROSCI.22-16-07244.2002
Manuela Gernert, Melanie Hamann, Mustapha Bennay, Wolfgang Löscher, Angelika Richter, Deficit of Striatal Parvalbumin-Reactive GABAergic Interneurons and Decreased Basal Ganglia Output in a Genetic Rodent Model of Idiopathic Paroxysmal Dystonia The Journal of Neuroscience. ,vol. 20, pp. 7052- 7058 ,(2000) , 10.1523/JNEUROSCI.20-18-07052.2000
Manuela Gernert, Angelika Richter, Wolfgang Löscher, Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters. Brain Research. ,vol. 821, pp. 277- 285 ,(1999) , 10.1016/S0006-8993(99)01080-X
P. S. A. Kalanithi, W. Zheng, Y. Kataoka, M. DiFiglia, H. Grantz, C. B. Saper, M. L. Schwartz, J. F. Leckman, F. M. Vaccarino, Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 13307- 13312 ,(2005) , 10.1073/PNAS.0502624102
Sandra Close Kirkwood, Jessica L. Su, P. Michael Conneally, Tatiana Foroud, Progression of Symptoms in the Early and Middle Stages of Huntington Disease JAMA Neurology. ,vol. 58, pp. 273- 278 ,(2001) , 10.1001/ARCHNEUR.58.2.273