Radiotherapy and the tumor microenvironment: mutual influence and clinical implications.

摘要: Ionizing radiation has been employed in targeted cancer treatments for more than a century because of its cytotoxic effects on cells. However, the responsiveness to and behavior tumors vivo may differ dramatically from observed behaviors isolated cells vitro. While not fully understood, these discrepancies are due complex constellation extracellular intercellular factors that together termed tumor microenvironment. Radiation alter or affect components adjacent microenvironment significant ways, often with consequences beyond direct itself. Moreover, different microenvironmental states, whether induced at baseline, can modulate even attenuate radiation, therapeutic efficacy. This chapter describes this bidirectional relationship detail, exploring role clinical implications respect irradiation.