Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases.

摘要: Inflammation is a homeostatic mechanism aiming to maintain tissue integrity. The underlying immunological mechanisms and the interrelationship between ionizing radiation inflammation are complex multifactorial on cellular chemical levels. On one hand, with single doses exceeding 1 Gy might initiate inflammatory reactions thereby impact tumor development. other capable of attenuating an established process, which clinically used for treatment degenerative diseases low-dose radiotherapy (single dose <1 Gy). At higher doses, radiation, especially in combination additional immune stimulation, fosters induction immunogenic forms cell death shifts microenvironment as well infiltration cells from anti- pro-inflammatory state. Distinct infiltrating predict response radiochemotherapy multitude entities. While high these adaptive mostly predicts favorable disease outcome, tumor-associated macrophages unfavorable response. Pro-inflammatory events should dominate over anti-inflammatory ones this scenario. This review focuses how modulates benign malign diseases. A special focus set role lymphocytes biomarkers anti-tumor immunity implicated effects therapy.