Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants

摘要: Abstract Islets of Langerhans treated with donor-specific anti-Ia serum and complement were transplanted across a major histocompatibility barrier into nonimmunosuppressed diabetic mice. The allografts survived in all recipients for at least 200 days after transplantation. Rejection an established allograft could be induced by intravenous injection donor splenocytes. This demonstrates that can serve as targets immune rejection supports the possible role Ia-positive passenger lymphoid cells initiation rejection. results show immunosuppression recipient is not prerequisite successful